Gerencia de Ciencias de la Vida, Fundación Instituto de Estudios Avanzados (IDEA), Caracas, Venezuela
ORCID:0000-0002-6318-3428
Dr. Raúl Isea
Address:
Carretera Nacional Hoyo de la Puerta, Valle de Sartenejas, Baruta, Caracas, Venezuela
Academic Metrics:
- h-index: 17
- i-10 index: 28
- Total Citations:959
Research Interests:
- Computational Biophysics
- Bioinformatics
- Molecular Modeling
- In Silico Drug Discovery
- Structural Biology
- Protein Dynamics
- DNA-Protein Interactions
- Computational Virology
- Chagas Disease
Biography:
Dr. Raúl Isea is a distinguished researcher in the field of computational biophysics at Venezuela's prestigious Foundation Institute for Advanced Studies (Fundación IDEA). His work is dedicated to unraveling the complex structures and functions of biological macromolecules, such as proteins and DNA, using powerful computational and bioinformatics tools. Dr. Isea specializes in in silico analysis and molecular modeling to investigate the mechanisms of various diseases, including Chagas disease, cancer, and viral infections like COVID-19. He is a pioneer in applying these advanced techniques to identify potential drug targets and design novel therapeutic inhibitors. His contributions are vital to advancing bioinformatics in Venezuela and have a global impact on the understanding of molecular medicine.
Education Details:
- PhD in Biophysics, Universidad Central de Venezuela, Venezuela (1998)
- MSc in Biology (Biophysics), Instituto Venezolano de Investigaciones Científicas, Venezuela (1992)
- BSc in Biology, Universidad Central de Venezuela, Venezuela (1988)
Professional Background:
- Researcher, Fundación Instituto de Estudios Avanzados (IDEA), Caracas, Venezuela (Present)
Achievements:
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A key figure in the development and application of bioinformatics and computational biology in Venezuela.
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Author of numerous publications in international journals, contributing to the understanding of various pathogens and diseases through computational methods.
Current Research Projects
His current work involves the in silico analysis of mutations in viral proteins, such as the spike protein of SARS-CoV-2 variants and the DNA polymerase of the monkeypox virus. He is also focused on identifying natural compounds that can act as potential inhibitors against viral and parasitic enzymes, contributing to early-stage drug discovery efforts.
Academic Profiles of Dr. Raúl Isea:
Publications:
Dr. Isea is a highly active researcher, consistently publishing his computational analyses of viral and parasitic proteins. His latest work provides timely insights into emerging infectious diseases like COVID-19 and monkeypox.
List of 5 Recent Publications:
- Isea, R. (2023). In silico analysis of the spike protein from the SARS-CoV-2 XBB. 1.5 variant identified in Venezuela. Gaceta Médica de Caracas, 131(3), 444-453.
- Isea, R., & Ramirez, J. L. (2023). Identification of natural compounds as potential inhibitors against monkeypox virus using molecular modeling. Journal of Applied Pharmaceutical Science, 13(7), 057-063.
- Isea, R. (2022). In silico analysis of mutations in the DNA polymerase of monkeypox virus. Gaceta Médica de Caracas, 130(4), 629-635.
- Isea, R. (2022). Analysis of the mutations in the spike protein of the SARS-CoV-2 Omicron variant. Journal of Human Virology & Retrovirology, 9(2), 43-46.
- Isea, R. (2022). A general view of the Bioinformatics in Venezuela. Gaceta Médica de Caracas, 130(Supl 1), S10-S23.
Last Updated on October 12, 2025